Multimodal Retinal Imaging Provides 'Insight' Into Cerebrovascular Ageing

Retinal hyperspectral imaging in mouse models of Parkinson’s disease and healthy aging

P Trlin, J Gong, KKN Tran, VHY Wong, PY Lee, A Hoang, D Zhao, LC Beauchamp, JKH Lim, A Metha, KJ Barnham, DI Finkelstein, BV Bui, P Bedggood, CTO Nguyen

2024-12-01

Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s ..

Levodopa Rescues Retinal Function in the Transgenic hA53T Alpha-Synuclein Model of Parkinson's Disease

Vickie Hoi Ying Wong, Katie KN Tran, Kirstan A Vessey, David I Finkelstein, Bang V Bui, Christine TO Nguyen

2024-06-01

Altered Outer Retinal Structure, Electrophysiology and Visual Perception in Parkinson's Disease

KKN Tran, PY Lee, DI Finkelstein, AM McKendrick, BN Nguyen, BV Bui, CTO Nguyen

2024-01-23

Background: Visual biomarkers of Parkinson's disease (PD) are attractive as the retina is an outpouching of the brain. Although in..

Levodopa Rescues Retinal Function in the Transgenic A53T Alpha-Synuclein Model of Parkinson’s Disease

KKN Tran, VHY Wong, KA Vessey, DI Finkelstein, BV Bui, CTO Nguyen

2024-01-01

Background: Loss of substantia nigra dopaminergic cells and alpha-synuclein (α-syn)-rich intraneuronal deposits within the central..

Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson’s disease

KKN Tran, VHY Wong, A Hoang, DI Finkelstein, BV Bui, CTO Nguyen

2023-01-01

Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of the pathological hallmarks of Parkinson’s d..

Characterization of retinal function and structure in the MPTP murine model of Parkinson’s disease

KKN Tran, VHY Wong, JKH Lim, A Shahandeh, A Hoang, DI Finkelstein, BV Bui, CTO Nguyen

2022-12-01

In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Par..

White matter tract conductivity is resistant to wide variations in paranodal structure and myelin thickness accompanying the loss of Tyro3: an experimental and simulated analysis

F Blades, JD Chambers, TD Aumann, CTO Nguyen, VHY Wong, A Aprico, EC Nwoke, BV Bui, DB Grayden, TJ Kilpatrick, MD Binder

2022-07-01

Myelination within the central nervous system (CNS) is crucial for the conduction of action potentials by neurons. Variation in co..

Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders

A Shahandeh, BV Bui, DI Finkelstein, CTO Nguyen

2022-02-03

Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iro..

Progressive impairments in executive function in the APP/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing

A Shepherd, JKH Lim, VHY Wong, AM Zeleznikow-Johnston, L Churilov, CTO Nguyen, BV Bui, AJ Hannan, EL Burrows

2021-12-01

Executive function deficits in Alzheimer's disease (AD) occur early in disease progression and may be predictive of cognitive decl..

Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer’s disease

JKH Lim, QX Li, T Ryan, P Bedggood, A Metha, AJ Vingrys, BV Bui, CTO Nguyen

2021-12-01

Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) pr..

Editorial: Seeing Beyond the Eye: The Brain Connection

CTO Nguyen, ML Acosta, S Di Angelantonio, TE Salt

2021-06-29

Increased episcleral venous pressure in a mouse model of circumlimbal suture induced ocular hypertension

VHY Wong, D Zhao, BV Bui, CJ Millar, CTO Nguyen

2021-01-01

Purpose: To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal sutu..

Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

A Shahandeh, BV Bui, DI Finkelstein, CTO Nguyen

2020-10-01

Iron is essential for normal cellular function, however, excessive accumulation of iron in neural tissue has been implicated in bo..

Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina

F Blades, VHY Wong, CTO Nguyen, BV Bui, TJ Kilpatrick, MD Binder

2020-08-14

Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons..

Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease

JKH Lim, QX Li, Z He, AJ Vingrys, HR Chinnery, J Mullen, BV Bui, CTO Nguyen

2020-08-13

Alzheimer’s disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia world..

Tyro3 is a key regulator of myelin structure and retinal function in the central nervous system

F Blades, VHY Wong, CTON Nguyen, BV Bui, TJ Kilpatrick, MD Binder

2020-03-01

Background: While it is evident how critical myelin is for neural signalling in the CNS, the biological processes underpinning mye..

Response of the trilaminar retinal vessel network to intraocular pressure elevation in rat eyes

D Zhao, Z He, L Wang, B Fortune, JKH Lim, VHY Wong, CTO Nguyen, BV Bui

2020-02-01

PURPOSE. The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus..

Age-Specific Retinal and Cerebral Immunodetection of Amyloid-β Plaques and Oligomers in a Rodent Model of Alzheimer's Disease

U Habiba, S Merlin, JKH Lim, VHY Wong, CTO Nguyen, JW Morley, BV Bui, M Tayebi

2020-01-01

Background: Amyloid-β soluble oligomers (Aβo) are believed to be the cause of the pathophysiology underlying Alzheimer's disease (..

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

X Hadoux, F Hui, JKH Lim, CL Masters, A Pébay, S Chevalier, J Ha, S Loi, CJ Fowler, C Rowe, VL Villemagne, EN Taylor, C Fluke, JP Soucy, F Lesage, JP Sylvestre, P Rosa-Neto, S Mathotaarachchi, S Gauthier, ZS Nasreddine

2019-12-01

Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, inclu..

A retinal imaging biomarker of Alzheimer's disease

Peter van Wijngaarden, Xavier Hadoux, Flora Hui, Jeremiah Lim, Christine Nguyen, Bang Bui, Jonathan Crowston

2019-11-01

Background: Amyloid-beta (Ab) deposition in the brain is a diagnostic marker for Alzheimer's disease (AD), but current tests are c..

Reversibility of retinal ganglion cell dysfunction from chronic IOP elevation

D Zhao, VHY Wong, CTO Nguyen, AI Jobling, EL Fletcher, AJ Vingrys, BV Bui

2019-09-01

PURPOSE. To test the hypothesis that the capacity for retinal ganglion cells to functionally recover from chronic IOP elevation is..

Evaluating retinal biomarkers in a mouse model of Parkinson's disease

Christine Tram Oanh Nguyen, Katie Tran, Jeremiah Kah Heng Lim, Vickie Hoi Ying Wong, Ali Shahandeh, Algis J Vingrys, Bang V Bui, David Finkelstein

2019-07-01

Purpose : The retina, an accessible outpouching of the central nervous system, may manifest cortical changes that occur with Parki..

The effect of TrkB receptor knockdown on mouse retinal ganglion cell function and their response to acute mild intraocular pressure stress

Vickie Hoi Ying Wong, Amy Wang, Christine Tram Oanh Nguyen, Jeremiah Kah Heng Lim, Madeline Nicholson, Junhua Xiao, Simon Murray, Bang V Bui

2019-07-01

Purpose : To examine the effect of tropomyosin receptor kinase B (TrkB) receptor removal on basal retinal ganglion cell (RGC) func..

Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats

D Zhao, CTO Nguyen, Z He, VHY Wong, AK Van Koeverden, AJ Vingrys, BV Bui

2018-12-01

Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the bra..

Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

AK Van Koeverden, Z He, CTO Nguyen, AJ Vingrys, BV Bui

2018-12-01

High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression ..

Morphological changes to retinal ganglion cells in a murine model of Alzheimer's disease

Vickie Wong, Christine Tram Oanh Nguyen, Patricia Jusuf, Jeremiah KH Lim, Mourad Tayebi, Bang V Bui

2018-07-01

Reversibility of retinal ganglion cell dysfunction due to chronic IOP elevation.

Da Zhao, Vickie Hoi Ying Wong, Zheng He, Christine Tram Oanh Nguyen, Andrew Ian Jobling, Erica Fletcher, Holly Chinnery, Patricia Jusuf, Jeremiah KH Lim, Algis J Vingrys, Bang V Bui

2018-07-01

Purpose : To determine the duration of chronic IOP elevation beyond which ganglion cell function can no longer recover using the m..

Retinal structural and functional changes in mouse models of Alzheimer’s and Parkinson’s disease

Christine Tram Oanh Nguyen, Jeremiah Lim, Vickie Wong, Bang Viet Bui, Algis Vingrys, Jamie Mullen, David Finkelstein

2018-01-01

Retinal and cortical blood flow dynamics following systemic blood-neural barrier disruption

F Hui, CTO Nguyen, Z He, AJ Vingrys, R Gurrell, RL Fish, BV Bui

2017-10-12

To consider whether imaging retinal vasculature may be used as a marker for cortical vessels, we compared fluorescein angiography ..

Retinal biomarkers provide “insight” into cortical pharmacology and disease

CTO Nguyen, F Hui, J Charng, S Velaedan, AK van Koeverden, JKH Lim, Z He, VHY Wong, AJ Vingrys, BV Bui, M Ivarsson

2017-07-01

The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of ..

The eye as a biomarker for Alzheimer's disease

JKH Lim, QX Li, Z He, AJ Vingrys, VHY Wong, N Currier, J Mullen, BV Bui, CTO Nguyen

2016-01-01

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading c..